DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends via a few nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic illness syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated https://andrewk615ubh7.robhasawiki.com/user